Biofilm Treatment Center

Biofilm is a protective shield manufactured by invading organisms to escape attacks from our antibodies and natural killer cells (immune system). Biofilm consists of a polysaccharide extracellular matrix described by microbiologists as a “super glue-like” substance.

Lyme spirochetes, Bartonella, and the mosquito parasite, Protomyxzoa Rheumatica, will wrap themselves in Biofilm if they are not immediately destroyed upon entry into our bloodstream. Thinking in three-dimensional terms, visualize Biofilm “bubbles” floating among red blood cells throughout the bloodstream.

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Clinical research at Sponaugle Wellness Institute has proven the quantity and consistency of Biofilm determines a multitude of outcomes. We believe two things cause chronic Lyme disease: 1) A suppressed immune system; and 2) Biofilm.
Biofilm would not exist if the patient were not immunocompromised.

Biofilm causes the “waxing and waning” – or feeling better temporarily after receiving antibiotic therapy – that many chronic Lyme disease patients experiences. These patients feel better temporarily after antibiotics effectively kill spirochetes in the free-floating bloodstream, where many Lyme disease symptoms originate. The problem is that the antibiotic therapy does not kill the spirochetes located inside the Biofilm formations that are floating through the bloodstream.

Several months later, the Biofilm-ridden spirochetes have produced enough offspring to reach a new critical mass effect, and they begin busting through the Biofilm. These spirochetes travel through the free-floating bloodstream, where they attack joints and multiple other organs, most concerning of which is the brain. For this reason, it is important to eradicate Biofilm formations in Lyme disease patients.

Treatment for Biofilm

While antibiotics can be very effective for killing Lyme Disease spirochetes and other bacteria in the “free-floating” bloodstream, antibiotics do not effectively penetrate the four-layer outer wall of Biofilm formations.

However, a small amount of antibiotics do get inside the Biofilm, but just enough to cause antibiotic resistance in Biofilm-protected bacteria.

Validating this concept are recent studies from the Center for Biofilm Engineering at Montana State University (MSU). The center’s research has proven that antibiotics do not effectively penetrate the protective Biofilm produced by Lyme disease spirochetes and other tick-borne microorganisms.

In fact, microbiologists at MSU have stated, “Antibiotic therapy not only fails to produce a bactericidal-kill in Biofilm-protected organisms, antibiotic therapy given before Biofilm has been adequately dissolved induces bacterial mutations, creating even more resistant phenotypes.”

According to the American Association of Quantum Medicine (AAQM), the more we use antibiotics to treat Biofilm-producing microorganisms, the stronger and more resistant they become. Furthermore, AAQM suggests Biofilm-producing, drug-resistant microorganisms can only be conquered by enhancing the killing power of the immune system.

For this reason, the Sponaugle Wellness Team has spent years designing and improving Integrative Lyme Disease Treatment, which enhances immune function, even in the most immunocompromised Lyme disease patients.

As a result, our patients have no difficulty destroying Biofilm.

In addition to destroying Biofilm, we also optimize brain function, which subsequently optimizes the immune function, as the brain ultimately modulates and activates an immune function.

In 2015, we made great advances in our clinic’s neurological protocol for “waking up” the neurotoxic brain of Lyme Disease patients. This has enabled the majority of his patients to begin destroying Biofilm within two- to three weeks after starting treatment*.

Is There A Place For Antibiotic Therapy In The Treatment of Tick-Borne Bacteria?

Absolutely. Once a patient’s immune function has been optimized, repeat testing is then used to prove the immune system is effectively destroying Biofilm, which then allows the use of antibiotic therapy.

When supplementing a healthy immune system, antibiotic therapy will provide a more “desired kill” of Borrelia spirochetes, and get patients home faster.

Of more importance, withholding antibiotic therapy in Neurological Lyme Disease patients demonstrates a lack of judgement.



Just-biofilm (1)
Hayden Lyme Disease Biofilm

Carol’s story is a good case study for validating the concept that antibiotics are extremely ineffective, if not worthless, in Lyme Disease patients, particularly those who have developed significant Biofilm. Dr. Sponaugle said, “Carol and her husband are one of the nicest couples I have met through 30 years of practicing medicine. Prior to finding Sponaugle Wellness Institute, Carol was treated for six years by the best and brightest LLMDs in New Jersey and New York.

“Over that six-year period, she was prescribed multiple antibiotics. Most significant is the fact that she was prescribed four grams of IV Rocephin daily for three years. Unfortunately, the Rocephin was ineffective in killing the massive Bartonella infection.” You can see this infection within the Biofilm formation on her blood smear below:

biofilm example

The last three years of excessive antibiotic treatment rendered Carol essentially bedridden.

“Carol’s Lyme Disease Treatment made her worse than the Lyme Disease infection itself, much like my daughter, Alexa, who had the same experience in her treatment,” said Dr. Sponaugle. “Our Lyme disease treatment in 2012 was not nearly as advanced as it is in 2016, and I credit Carol’s amazing transformation – in just three months* – to the fact that she is truly a Christian woman who sincerely prayed for, and believed in, her recovery.”

Our Research Has Proven Biofilm Contains Mold Toxins and Industrial Toxins

brain scan

Carol was the first patient in which the team at Sponaugle Wellness Institute was able to determine that Mold Toxins and Industrial Toxins are sequestered in Biofilm formations.

“Because Carol’s husband was a brilliant mathematician, he wanted, like me, to prove or disprove concepts with numerical data, not guess work,” said Dr. Sponaugle. “Therefore he allowed me to perform testing precisely before and immediately after we used our “biofilm-busting” IV Infusions.”
“To prove many of my theories through clinical research, we have had to eliminate variables, perform biomarker testing with precise before-and-after time frames, and use deductive reasoning. Patients remain the best teachers, if we pay attention,” Dr. Sponaugle said.



Dr. Sponaugle’s opinion is that a healthy immune system does not allow significant Biofilm to “build up” in the bloodstream. He has proven this concept through correlation of mathematical biomarkers for the immune function, and through hundreds of blood smears. The longer a patient has unknowingly suffered from toxin-induced immune suppression, the higher probability he/she will have for significant biofilm formation, as seen in Carol’s blood smear above.


Another variable that determines whether patients will have excessive Biofilm is exposure. This doesn’t necessarily mean long-term immune suppression, but a patient may still have significant Biofilm if he/she has had excessive exposure to mosquitoes and ticks.

If you are, as many spouses have jokingly stated “my mosquito repellant,” you most likely have excessive Biofilm formation. Mosquitos are drawn to patients with higher lactic acid levels. Why? Toxic patients suffer from more hypercoaguability and excessive clotting, which decreases blood flow in the microcirculation, causing a reduction of oxygen delivery and subsequently excessive lactic acid production.

Lastly, an anecdotal, non-scientific Sponaugle-ism: “Patients who have abnormal ‘welts’ from mosquito bites typically have more mosquito-borne pathogens that have been injected into their bloodstream. Hence, they develop excessive antibodies to mosquito-borne parasites. The mosquito parasite, Protomyxzoa Rheumatica, is extremely ‘gifted’ at producing Biofilm.”

*Sponaugle Wellness Institute cannot guarantee individual patient outcomes.
Treatment results will vary from patient to patient.