Brain Wellness

Consequences of Increased Toxin Levels

Neurotransmitter testing of brain toxins
3 min read

At the 2017 IMMH conference in Los Angeles, Dr. Sponaugle presented clinical research that correlated thousands of toxin levels with changes in Neurotransmitter testing.

Our clinical research has correlated specific lipophilic toxins levels, some mold mycotoxins, and some petroleum-based toxins, with the reduction of enzyme activity.

There is an obvious inverse relationship, the higher the level of the circulating toxin, the more down-regulation of the specific enzyme activity.

Our clinical research was performed with timely and precise clinical testing.

Toxin levels and Neurotransmitter ratios were measured immediately before, and immediately after sufficient IV Glutathione was given to minimize the circulating toxin level.

The increased function of the converting enzyme occurred almost immediately following an aggressive IV infusion of Glutathione, in approximately one or two circulation times following a Glutathione.

A great example of this phenomenon is often seen when patients suffer Ochratoxin poisoning. Extremely high levels of the mycotoxin, Ochratoxin, down-regulate the function, and subsequently, the natural downstream conversion of Dopamine to Norepinephrine.

Ochratoxin floating throughout the bloodstream at significant levels will down-regulate the natural “downstream” conversion of Dopamine to Norepinephrine.

The Ochratoxin attaches to the enzyme “Dopamine Beta Hydroxylase” and prevents an efficacious conversation of Dopamine to Norepinephrine.

This phenomenon does not occur when the Ochratoxin is sequestered within the polysaccharide “glue” of the Biofilm formations spun by Lyme spirochetes and other foreign infectious agents.

I have successfully treated many Autistic children who were poisoned by Ochratoxin, usually from a basement bedroom.

While I consider optimal levels of Dopamine on Neurotransmitter testing to range from 170 to 190, these Autistic children often suffer from excessive Dopamine levels of 600 to 1000.

Dopamine levels at 800 can cause severe panic disorder, paranoia, bipolar behavior, and severe tachycardia.

Dopamine activates the Beta One neuron receptor on cardiac neurons and the primary cardiac pacemaker, the SA node.

Hence, extremely elevated Dopamine levels of 600 to 800 can cause severe Sinus Tachycardia, and worse, Cardiac Irritability in which all of the Atrial Neurons attempt to take over the responsibility of controlling heart rate – this can cause Atrial arrhythmias and even Atrial Fibrillation.

The longer the Autistic child is allowed to play in a basement that is saturated with Ochratoxin gas, the more damage their brain sustains.

The flip side of Ochratoxin-induced shut down of the enzyme “Dopamine Beta Hydroxylase” is that the patient suffers from severe suboptimal Norepinephrine levels.

Norepinephrine activates the Aloha One nerve receptor which is responsible for maintaining vascular tone, especially when the patient makes a postural change from sitting to standing.

Normal Norepinephrine levels range 35 to 45, the Ochratoxin-induced down-regulation of Dopamine Beta Hydroxylase leaves these patients with Norepinephrine levels as low as 4 or 5.

These patients suffer tremendous POTS issues because they have insufficient Norepinephrine to attach to the nerve receptors on the vascular blood vessels.

They suffer from a reduced venous return to the heart because the blood simply “pools” in their dependent extremities.

The resultant diminished blood flow returning to the heart is known as “cardiac filling pressure.”

Cardiac filling pressure increases the muscular squeeze of the left ventricle and subsequently, increases cardiac output.

Through deductive reasoning, we can clearly comprehend how severe Ochratoxin poisoning can cause a dangerous chain of events that have the potential to compromise the entire cardiovascular system.

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About Sponaugle Wellness Institute

At Sponaugle Wellness Institute we practice integrative medicine, combining the best of conventional and alternative medicine to focus on outcome-based treatments for patient. Our mission is to diagnose and treat the underlying cause of our patient’s illness rather than to treat their symptoms. Dr. Rick Sponaugle, Director of Sponaugle Wellness Institute, is an integrative physician with extraordinary brain expertise having treated over 8,000 patients who were suffering with various psychological and neurological disorders.a

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